Table 2.

Unadjusted Associations for Top 5 Single SNPs Contributing to Race/Ethnicity-specific Genetic Risk Scores

	Gene	Coded/ Non-coded Allele	Moderate + Severe Venous Disease OR (95% CI)	p-value
White, n = 898
rs1799810	PROC	A/T	1.28 (1.06, 1.54)	0.01
rs2192824	TFPI	C/T	1.23 (1.01,1.50)	0.04
rs1039084	STXBP5	A/G	1.20 (0.99.1.46)	0.06
rs670659	RGS7	C/T	1.19 (0.97, 1.45)	0.09
rs1613662	GP6	A/G	1.26 (0.96,1.64)	0.09
African-Americans, n = 165
rs3756008	KLKB1	A/G	2.89 (1.09.7.67)	0.03
rs2036914	F11	T/C	1.62 (0.98, 2.66)	0.06
rs1800788	FGB	T/C	1.83 (0.84, 4.01)	0.13
rs1799810	PROC	A/T	1.39 (0.87, 2.22)	0.16
rs2069915	PROC	A/G	1.38 (0.84, 2.27)	0.20
Hispanic, n = 207
rs5985	F13A1	A/C	2.11 (1.27, 3.51)	0.004
rs1039084	STXBP5	A/G	1.52 (1.03, 2.26)	0.04
rs2289252	F11	C/T	1.48 (0.96, 2.28)	0.07
rs8176720	ABO	C/T	1.32 (0.89, 1.99)	0.17
rs7853989	ABO	G/C	1.70 (0.79, 3.69)	0.18
Asians, n = 177
rs2227564	PLAU	C/T	1.62 (1.02, 2.55)	0.04
rs1799810	PROC	A/T	1.84 (0.98, 3.47)	0.06
rs1039084	STXBP5	A/G	1.65 (0.97, 2.82)	0.06
rs253061	F2R	A/C	1.48 (0.88, 2.48)	0.14
rs2069915	PROC	A/G	1.38 (0.87, 2.21)	0.17