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. Author manuscript; available in PMC: 2016 Jan 19.
Published in final edited form as: Mol Reprod Dev. 2010 Oct 7;77(12):1001–1015. doi: 10.1002/mrd.21242

Figure 1.

Figure 1

Nuclear remodeling in donor cells, zygotes, and SCNT zygotes (not drawn to scale as the donor cell and nucleus would be smaller). The donor cell is drawn in a pipette. Different figures and colors are used to depict the location and concentration of a variety of proteins that have been localized in donor nuclei, zygotes and SCNT zygotes (ZP, zona pellucida; PM, plasma membrane; NE, nuclear envelope). Data are based upon the following manuscripts: using a blastomere as a nuclear donor cell (Prather et al., 1989, 1990, 1991, 2000; Kubiak et al., 1991; Prather and Rickords, 1992; Parry and Prather, 1995) or fetal fibroblast as a nuclear donor cell (Park et al., 2001b; Moreira et al., 2003; Gao et al., 2004; Mananadhar et al., 2004; Novak et al., 2004; Teranishi et al., 2004; Sutovsky et al., 2005; Liu et al., 2006; Antelman et al., 2008; Chang et al., 2010; Zhao et al., 2010a). A more complete description of differences in histone acetylation and DNA methylation in donor cells, zygotes and SCNT embryos has recently been published (Zhao et al., 2010b).