Table 3. Frequencies of alleles and genotypes of REL and PRKCQ polymorphisms in patients and controls.
| SNP | GenotypeAllele | Cases (N = 623) | Controls (N = 1,074) | P-value | Pc | P-valuea | Pca | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| rs842647 | AA | 7 (1.12) | 21 (1.96) | 0.195 | NS | 0.23 | NS | 0.57 (0.24–1.35) |
| AG | 95 (15.25) | 239 (22.25) | 0.00047 | 0.011 | 0.001 | 0.024 | 0.63 (0.48–0.82) | |
| GG | 521 (83.63) | 814 (75.79) | 0.00015 | 0.0036 | 0.00031 | 0.0074 | 1.63 (1.27–2.10) | |
| A | 109 (8.75) | 281 (13.08) | 0.00014 | 0.0034 | 0.000302 | 0.0072 | 0.64 (0.50–0.80) | |
| G | 1,137 (91.25) | 1,867 (86.92) | 0.00014 | 0.0034 | 0.000302 | 0.0072 | 1.57 (1.24–1.98) | |
| rs702873 | AA | 14 (2.25) | 29 (2.70) | 0.567 | NS | NS | NS | 0.83 (0.43–1.58) |
| AG | 136 (21.83) | 257 (23.93) | 0.323 | NS | NS | NS | 0.89 (0.70–1.12) | |
| GG | 473 (75.92) | 788 (73.37) | 0.246 | NS | NS | NS | 1.14 (0.91–1.44) | |
| A | 164 (13.16) | 315 (14.66) | 0.226 | NS | NS | NS | 0.88 (0.72–1.08) | |
| G | 1,082 (86.84) | 1,833 (85.34) | 0.226 | NS | NS | NS | 1.13 (0.93–1.39) | |
| rs13031237 | GG | 600 (96.31) | 1,032 (96.09) | 0.821 | NS | NS | NS | 1.06 (0.63–1.78) |
| GT | 23 (3.69) | 42 (3.91) | 0.82 | NS | NS | NS | 0.94 (0.56–1.58) | |
| G | 1,223 (98.15) | 2,106 (98.04) | 0.82 | NS | NS | NS | 1.06 (0.64–1.77) | |
| T | 23 (1.85) | 42 (1.96) | 0.82 | NS | NS | NS | 0.94 (0.56–1.58) | |
| rs4750316 | CC | 510 (81.86) | 893 (83.15) | 0.50 | NS | NS | NS | 0.92 (0.71–1.19) |
| GC | 104 (16.69) | 174 (16.20) | 0.79 | NS | NS | NS | 1.04 (0.80–1.35) | |
| GG | 9 (1.44) | 7 (0.65) | 0.103 | NS | NS | NS | 2.23 (0.83–6.03) | |
| C | 1,124 (90.21) | 1,960 (91.25) | 0.31 | NS | NS | NS | 0.88 (0.70–1.12) | |
| G | 122 (9.79) | 188 (8.75) | 0.31 | NS | NS | NS | 1.13 (0.89–1.44) | |
| rs11258747 | GG | 550 (88.28) | 928 (86.41) | 0.27 | NS | NS | NS | 1.19 (0.88–1.60) |
| GT | 72 (11.56) | 144 (13.41) | 0.27 | NS | NS | NS | 0.84 (0.62–1.14) | |
| TT | 1 (0.16) | 2 (0.19) | 0.90 | NS | NS | NS | 0.86 (0.08–9.52) | |
| G | 1,172 (94.06) | 2,000 (93.11) | 0.28 | NS | NS | NS | 1.17 (0.88–1.56) | |
| T | 74 (5.94) | 148 (6.89) | 0.28 | NS | NS | NS | 0.85 (0.64–1.14) | |
| rs947474 | AA | 422 (67.74) | 736 (68.53) | 0.74 | NS | NS | NS | 0.96 (0.78–1.19) |
| AG | 174 (27.93) | 311 (28.96) | 0.65 | NS | NS | NS | 0.95 (0.76–1.18) | |
| GG | 27 (4.33) | 27 (2.51) | 0.04 | NS | NS | NS | 1.76 (1.02–3.02) | |
| A | 1,018 (81.70) | 1,783 (83.01) | 0.33 | NS | NS | NS | 0.91 (0.76–1.10) | |
| G | 228 (18.30) | 365 (16.99) | 0.33 | NS | NS | NS | 1.09 (0.91–1.31) |
Pc: Bonferroni corrected P-value
Pca: Bonferroni-corrected P-value for gender adjustment
a: Gender-adjusted P-value
CI: confidence interval; OR: odds ratio