Table 1.

Effects of tefluthrin and deltamethrin on the voltage dependence of activation of sodium channels expressed in HEK-Na_v1.6 and HEK-Na_v1.6β1 cells.^a

	HEK-Nav1.6 cells			HEK-Nav1.6β1 cells
Condition	V0.5	K	n	V0.5	K	n
Control	−35.2 ± 0.8*b	4.19 ± 0.17*	64	−28.6 ± 0.8*c	4.90 ± 0.12*	65
+ Tefluthrin
0.1 μM	−39.9 ± 1.1†	3.50 ± 0.34*	20	−33.6 ± 1.5*	5.02 ± 0.19*	13
1 μM	−41.5 ± 1.4†‡	4.44 ± 0.34*	19	−41.6 ± 1.2†	6.17 ± 0.32†	36
10 μM	−42.0 ± 1.2†‡	4.79 ± 0.49*	10	−43.6 ± 2.2†‡	6.85 ± 0.33†	10
100 μM	−47.7 ± 2.2‡	5.20 ± 0.60*	11	−48.9 ± 2.8‡	6.57 ± 0.32†	10
+ Deltamethrin
0.1 μM	−45.3 ± 1.6†	3.87 ± 0.29*	19	−34.9 ± 2.6†	4.39 ± 0.25*	15
1 μM	−45.6 ± 1.9†	4.62 ± 0.37*	23	−37.2 ± 2.3†	5.17 ± 0.32*	18
10 μM	−50.3 ± 2.0†	4.41 ± 0.25*	14	−38.3 ± 3.2†	4.84 ± 0.31*	12

^aValues calculated from fits of the data from the indicated number of individual experiments to the Boltzmann equation; V_0.5, midpoint potential (mV) for voltage-dependent activation; K, slope factor; data in the absence of insecticides are pooled values for all HEK-Na_v1.6 and HEK-Na_v1.6β1 cells tested (He and Soderlund, 2014).

^bValues in each column for control and concentrations of either tefluthrin or deltamethrin that are marked with the different symbols were significantly different.