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. Author manuscript; available in PMC: 2016 Jun 14.
Published in final edited form as: Nat Chem Biol. 2015 Dec 14;12(2):109–116. doi: 10.1038/nchembio.1986

Figure 5. Large numbers of CCLs are required to identify MoA.

Figure 5

(a) Significance of connection between austocystin D AUC and CYP2J2 expression (black), and ML239 AUC and FADS2 expression (blue) as a function of CCL number in non-HL CCLs. Red, Bonferroni-corrected z-score cutoff (|z| > 4.79) for random sampling of CCLs. (b) Simulation of whether connections to 43 small molecules listed in Supplementary Table 1 could be identified using smaller numbers of CCLs. Depicted are the fraction (red trace) of connections that were statistically significant relative to the null distribution after Bonferroni correction for multiple hypothesis testing. Correlations one standard deviation above or below the mean are in gray.