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. Author manuscript; available in PMC: 2017 Jan 28.
Published in final edited form as: J Control Release. 2015 Dec 17;222:169–175. doi: 10.1016/j.jconrel.2015.12.025

Fig. 1.

Fig. 1

Endothelial cells functionalized with polylactide-based MNP. Intracellular localization of MNP internalized by rat aortic endothelial cells over 24 h in presence of a high-gradient field (32.5 T/m) is visualized by fluorescent microscopy using particles stably labeled with BODIPY558/568 (merged bright field and red fluorescent image shown in A, original magnification ×400). Polylactide-based MNP formulated with 43% magnetite (w/w) exhibit strong magnetization at 1 kOe (uniform field strength used for in vivo studies) and a lack of remanence (B). Consistent with the particle magnetization pattern, MNP-functionalized cells show strong yet fully reversible magnetization (0.6 nemu per cell at 1 kOe) absent in control (unloaded) cells (C).