Figure 3.
Association of p16INK4a mRNA levels in PBTLs (peripheral blood T-lymphocytes) with other markers of aging: (a) Chronologic age; (b) Ratio of p16 protein level in LIMA (left internal mammary artery) versus p16 protein level in aorta; (c) Augmentation index; (d) Cerebral oximetry; (e) Exercise intensity; (f) Smoking; (g) Interleukin 6 levels. Dots indicate individual data, red line is a line from univariate linear regression of p16INK4a mRNA levels in PBTLs on variables mentioned in (a)-(f). Figures (a)-(d) reflect a priori analyses, figures (e)-(g) reflect secondary analyses. Correlation coefficients (r) and p-values are provided for each marker of aging in association with p16INK4a mRNA levels in PBTLs; p-value<0.05 was considered significant.