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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Psychiatry Clin Neurosci. 2015 Oct 8;70(1):51–61. doi: 10.1111/pcn.12357

Figure 2. Dorsal Anterior Cingulate, Posterior-Medial Orbitofrontal, Amygdala, and Inferior Frontal Gyrus Activation Changes Post- vs. Pre-Transference-Focused Psychotherapy Correlated With Clinical Improvement.

Figure 2

Panels A–D depict correlational analyses of post vs. pre-treatment related effects on constraint, affective lability, and aggression for the interaction [(post-treatment vs. pre-treatment) × (negative vs. neutral) × (no-go vs. go)] (Supplementary Table 2 and 4). Statistical parametric maps are thresholded at a voxelwise p-value of 0.01. Panel A shows a positive correlation between improvements in Multidimensional Personality Questionnaire (MPQ) – Constraint score and relative increased activation in the left anterior-dorsal anterior cingulate cortex (voxel-wise p-value < 0.001, corrected p-value=0.002). Panel B shows a positive correlation between improvements in Affective Lability Scale (ALS) – Total score and relative increased activation in the left posterior-medial orbitofrontal cortex/ventral striatum (voxel-wise p-value=0.001, corrected p-value=0.028). Panel C shows a negative correlation between improvements in ALS-Total score and relative decreased activation in the right amygdala/parahippocampal cortex (voxel-wise p-value < 0.001, corrected p-value=0.005). Panel D shows a positive correlation between improvements in Overt Aggression Scale-Modified (OAS-M) aggression score and relative increased activation in the left inferior frontal gyrus (voxel-wise p-value=0.001). X-axes formatted so that increasing values reflect clinical improvement.