Table 2.
Ductal Carcinoma In-Situ | Invasive Breast Cancer | ||||
---|---|---|---|---|---|
Characteristic | Category | OR (95% CI)a | p-value | OR (95% CI)a | p-value |
Age Group, years | 66-69 | Referent | <0.0001 | Referent | <0.0001 |
70-74 | 0.88 (0.75, 1.03) | 0.80 (0.74, 0.86) | |||
75-79 | 0.67 (0.56, 0.80) | 0.60 (0.55, 0.65) | |||
80-84 | 0.44 (0.36, 0.56) | 0.39 (0.36, 0.43) | |||
85+ | 0.23 (0.16, 0.33) | 0.20 (0.18, 0.23) | |||
Race | White | Referent | 0.84 | Referent | <0.0001 |
Black | 0.92 (0.69, 1.21) | 0.77 (0.67, 0.88) | |||
Other | 0.89 (0.68, 1.18) | 0.79 (0.69, 0.90) | |||
SEER Registry | California | Referent | <0.0001 | Referent | <0.0001 |
Utah | 0.52 (0.31, 0.87) | 0.65 (0.54, 0.79) | |||
Seattle | 1.37 (1.06, 1.77) | 1.72 (1.54, 1.91) | |||
San Jose | 0.45 (0.29, 0.71) | 0.51 (0.42, 0.62) | |||
San Francisco | 0.32 (0.21, 0.47) | 0.44 (0.37, 0.53) | |||
Rural Georgia | 0.41 (0.05, 3.43) | 0.43 (0.19, 0.95) | |||
New Mexico | 1.58 (0.98, 2.55) | 2.09 (1.74, 2.51) | |||
New Jersey | 0.70 (0.57, 0.87) | 0.69 (0.63, 0.76) | |||
Louisiana | 0.53 (0.38, 0.74) | 0.53 (0.45, 0.61) | |||
Los Angeles | 1.20 (0.93, 1.55) | 1.54 (1.38, 1.71) | |||
Kentucky | 0.18 (0.12, 0.29) | 0.28 (0.23, 0.33) | |||
Iowa | 0.35 (0.23, 0.52) | 0.42 (0.35, 0.49) | |||
Hawaii | 0.10 (0.04, 0.29) | 0.08 (0.04, 0.15) | |||
Greater Georgia | 0.38 (0.28, 0.51) | 0.40 (0.35, 0.46) | |||
Detroit | 0.31 (0.22, 0.45) | 0.53 (0.46, 0.62) | |||
Connecticut | 0.68 (0.52, 0.89) | 0.75 (0.66, 0.84) | |||
Atlanta | 0.84 (0.60, 1.17) | 0.64 (0.54, 0.76) | |||
Residenceb | Urban | Referent | 0.49 | Referent | 0.87 |
Rural | 1.12 (0.80, 1.57) | 1.01 (0.89, 1.15) | |||
Married | Married | Referent | <0.0001 | Referent | <0.0001 |
Not married | 0.75 (0.65, 0.86) | 0.87 (0.82, 0.92) | |||
Median Income | <= $35,800 | Referent | <0.0001 | Referent | <0.0001 |
$35,801-$47,300 | 1.42 (1.14, 1.76) | 1.32 (1.21, 1.45) | |||
$47,301-$64,200 | 1.62 (1.3, 2.02) | 1.58 (1.44, 1.73) | |||
>$64,200 | 2.02 (1.62, 2.52) | 2.21 (2.01, 2.43) | |||
Comorbidity Scorec | None | Referent | <0.0001 | Referent | <0.0001 |
1 | 0.77 (0.66, 0.90) | 0.78 (0.73, 0.84) | |||
2+ | 0.60 (0.47, 0.75) | 0.57 (0.51, 0.62) | |||
Diagnosis Year | 2005 | Referent | <0.0001 | Referent | <0.0001 |
2006 | 1.57 (1.20, 2.06) | 1.67 (1.50, 1.86) | |||
2007 | 2.98 (2.31, 3.85) | 3.05 (2.75, 3.39) | |||
2008 | 5.41 (4.25, 6.90) | 4.42 (4.00, 4.89) | |||
2009 | 4.94 (3.87, 6.31) | 4.94 (4.47, 5.46) | |||
Histology | Invasive Ductal | Referent | <0.0001 | ||
Invasive Lobular | 1.95 (1.80, 2.12) | ||||
Invasive Lobular & Ductal | 1.57 (1.42, 1.74) | ||||
Invasive Other | n/a | 0.87 (0.78, 0.98) | |||
Grade | Low | Referent | 0.56 | Referent | 0.01 |
Intermediate | 0.91 (0.78, 1.07) | 1.10 (1.02, 1.19) | |||
High | 0.96 (0.77, 1.20) | 1.09 (1.00, 1.10) | |||
Unknown | 0.89 (0.73, 1.09) | 0.93 (0.80, 1.08) | |||
Stage | I | Referent | 0.01 | ||
II | n/a | 1.18 (1.09, 1.28) | |||
III | 1.07 (0.94, 1.21) | ||||
Tumor Size | <1cm | Referent | <0.0001 | Referent | 0.0003 |
1 to <2cm | 1.09 (0.91, 1.31) | 1.04 (0.97, 1.12) | |||
2cm to <5cm | 1.30 (1.07, 1.58) | 0.83 (0.75, 0.92) | |||
5+ cm | 1.68 (1.24, 2.28) | 0.76 (0.65, 0.90) | |||
Unknown | 0.82 (0.68, 0.97) | 0.95 (0.74, 1.22) | |||
Estrogen Receptor | Positive | Referent | 0.05 | Referent | 0.001 |
Negative | 1.13 (0.94, 1.35) | 1.14 (1.04, 1.24) | |||
Unknown | 0.84 (0.70, 0.99) | 0.81 (0.69, 0.94) | |||
Teaching Hospitald | No | Referent | 0.58 | Referent | 0.01 |
Yes | 0.95 (0.81, 1.12) | 1.09 (1.02, 1.17) | |||
Unknown | 0.63 (0.23, 1.72) | 1.44 (0.98, 2.11) | |||
Member of NCI Cooperative Group Triale | No | Referent | <0.0001 | Referent | <0.0001 |
Yes | 1.97 (1.66, 2.33) | 1.94 (1.81, 2.07) | |||
Unknown | 2.08 (0.75, 5.78) | 0.97 (0.66, 1.43) |
OR = odds ratio; 95%CI = 95% confidence interval.
Residence is based on the woman's county of residence at time of breast cancer diagnosis and is categorized into urban which includes big metropolitan, metropolitan, and urban versus rural which includes less urban and rural counties.
Comorbidity Index is based on the method of Klabunde et al.(14)
Teaching hospital is based on the hospital where the breast surgery was performed.
Membership in an NCI Cooperative group trial indicates if the hospital where the surgery was performed participated in at least one NCI trial.