Table 2. Changes in the spatial firing properties of CA1 neurons were even across groups, with a greater degree of spatial information changes in ArchT rats on laser intervention days.

The median changes in mean firing rate, max firing rate, and spatial information (Δ = Intervention - Baseline) were not significantly different across Laser intervention and Sham-Laser intervention days or across ArchT or GFP treatment groups. The distribution of changes in spatial information was significantly different between ArchT_Laser and ArchT_Sham-Laser days and between ArchT_Laser and GFP_Laser groups.

Comparison	Δ Mean Rate				Δ Max Rate				Δ Information
	Mann-Whitney U		K-S		Mann-Whitney U		K-S		Mann-Whitney U		K-S
	p-value	U-value	p-value	K-S stat	p-value	U-value	p-value	K-S stat	p-value	U-value	p-value	K-S stat
ArchTLaser ArchTSham-Laser	0.9393	0.0761	0.9393	0.0761	0.5469	0.6025	0.0761	0.0994	0.9112	0.1116	0.0423	0.1079
ArchTLaser GFPLaser	0.1215	1.5484	0.1215	1.5484	0.4984	0.6770	0.4915	0.0685	0.0878	1.7071	0.0561	0.1100
ArchTLaser GFPSham-Laser	0.8327	0.2111	0.8327	0.2111	0.9166	0.1047	0.4618	0.0735	0.6389	0.4693	0.1714	0.0955
ArchTSham-Laser GFPLaser	0.1384	1.4814	0.1384	1.4814	0.8794	0.1518	0.9244	0.0476	0.0529	1.9359	0.0701	0.1123
ArchTSham-Laser GFPSham-Laser	0.7891	0.2674	0.7891	0.2674	0.5600	0.5828	0.7843	0.0592	0.5514	0.5957	0.7843	0.0592
GFPLaser GFPSham-Laser	0.2830	1.0734	0.2830	1.0734	0.4936	0.6845	0.7180	0.0656	0.2031	1.2728	0.1366	0.1093
Median Values:	ArchTLaser = −0.03 Hz ArchTSham-Laser = −0.09 GFPLaser = −0.02 GFPSham-Laser = −0.08				ArchTLaser = −0.29 Hz ArchTSham-Laser = −0.57 GFPLaser = −0.34 GFPSham-Laser = −0.67				ArchTLaser = 0.01 bits/spike ArchTSham-Laser = −0.02 GFPLaser = −0.16 GFPSham-Laser = −0.05