Table 2.
Risk Factors Analyzed for 30-Day Mortality
| Characteristic | BTT with CF LVAD (n=2,152)
|
|
|---|---|---|
| N | % or median (5th–95th percentile) | |
| Demographics | ||
| Male Recipient | 1,756 | 81.6% |
| Male Donor | 1,660 | 77.1% |
| Female Recipient/Female Donor | 206 | 9.6% |
| Female Recipient/Male Donor | 190 | 8.8% |
| Male Recipient/Female Donor | 286 | 13.3% |
| Male Recipient/Male Donor | 1,470 | 68.3% |
| ABO Identical | 1,899 | 88.2% |
| Recipient Age (years) | 2,152 | 56.0 (27.0–68.0) |
| Recipient Body Mass Index (kg/m^2) | 2,152 | 27.7 (20.4–36.3) |
| Donor Age (years) | 2,152 | 29.0 (17.0–51.0) |
| Donor Height (cm) | 2,146 | 177.8 (160.0–190.0) |
| Donor Weight (kg) | 2,146 | 83.0 (59.0–118.0) |
| Diagnosis | ||
| Idiopathic Cardiomyopathy | 938 | 43.6% |
| Ischemic Cardiomyopathy | 911 | 42.3% |
| Other Cardiomyopathy | 259 | 12% |
| Valvular Heart Disease | 24 | 1.1% |
| Congenital Heart Disease | 12 | 0.6% |
| Other Heart Disease | 8 | 0.4% |
| Condition at Transplant | ||
| ICU | 185 | 8.6% |
| Hospitalized, not ICU | 271 | 12.6% |
| ECMO | 5 | 0.2% |
| IABP | 15 | 0.7% |
| Ventilator | 15 | 0.7% |
| Inotropes | 160 | 7.5% |
| Medical History | ||
| Diabetes | 646 | 30% |
| History of Dialysis | 52 | 2.5% |
| Hypertension | 948 | 49.4% |
| COPD | 91 | 5.3% |
| Antiarrhythmic Medications | 633 | 38% |
| Implantable Defibrillator | 1,776 | 87.6% |
| Prior Cardiac Surgery | 1,520 | 70.9% |
| Serum Creatinine (mg/dL) | 2,135 | 1.1 (0.7–2.0) |
| Total Bilirubin (mg/dL) | 2,084 | 0.7 (0.3–2.4) |
| Serum Albumin (g/dL) | 1,727 | 3.7 (2.5–4.6) |
| Ischemic Time (hours) | 2,115 | 3.3 (1.6–5.0) |
| Serology | ||
| Recipient CMV IgG | 1,249 | 59% |
| Recipient CMV IgM | 74 | 3.6% |
| Recipient Hepatitis B Core Antibody | 99 | 4.7% |
| Recipient Hepatitis B Surface Antigen | 34 | 1.6% |
| Recipient Hepatitis C Serostatus | 55 | 2.6% |
| Recipient Epstein Barr Virus Serostatus | 1,630 | 79.6% |
| Donor Anti-CMV Antibody | 1,301 | 60.7% |
| Donor HBV Core Antibody | 44 | 2.1% |
| Donor HBV Surface Antigen | 2 | 0.1% |
| Donor Anti-HCV Antibody | 0 | 0% |
| Donor EBV IgG | 1,883 | 90.1% |
| Donor EBV IgM | 58 | 2.8% |
| Donor RPR-VDRL | 4 | 0.2% |
| Donor/Recipient CMV Mismatch | 1,009 | 46.9% |
| Donor/Recipient EBV Mismatch | 303 | 14.1% |
BTT, Bridge to Transplant; CF, Continuous Flow; CMV, Cytomegalovirus; COPD, Chronic Obstructive Pulmonary Disease; EBV, Epstein Barr Virus; ECMO, Extracorporeal Membrane Oxygenation; HBV, Hepatitis B Virus; HCV, Hepatitis C Virus; IABP, Intraaortic Balloon Pump; ICU, Intensive Care Unit; IgG, Immunoglobulin G; IgM, Immunoglobulin M; LVAD, Left Ventricular Assist Device; RPR-VDRL, Rapid Plasma Reagin – Venereal Disease Research Laboratory.