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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Horm Behav. 2015 Oct 21;78:60–66. doi: 10.1016/j.yhbeh.2015.10.013

Figure 4. Leuprolide acetate rescues the total number of spines on dendritic outgrowths after ovariectomy.

Figure 4

OVX-associated decreases in spine density are rescued by leuprolide acetate treatment in the no delay cohort, and leuprolide acetate increases spine density when a 4 month delay is present between treatment and OVX (4M Delay). A: Leuprolide acetate exhibited an ability to rescue the total number of spines regardless of treatment onset after OVX (one-way ANOVA). B: Representative images of dendritic segments. C: The number of thin spines was rescued when treatment with leuprolide acetate began on the OVX day. D: The number of mushroom spines was increased by leuprolide acetate treatment with a 4 month delay between OVX and treatment onset. Results are expressed as mean ± sem. Significant difference (p<0.05) from SHAM+SAL (a), from OVX+SAL (b), from OVX+LA (c) and from OVX+E2 (d) SHAM+SAL, sham ovariectomy treated with saline; OVX+SAL, ovariectomy treated with saline; OVX+E2, ovariectomy treated with 17β-estradiol; OVX+LA, ovariectomy treated with leuprolide acetate