Table 2.
Differences in demographic and clinical characteristics between patients with and without seizure reduction at 6, 12 and 18 months after the start of temozolomide
| Seizure reduction at 6mo (n = 51) | Seizure reduction at 12mo (n = 38) | Seizure reduction at 18mo (n = 34) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| <50 % | ≥50 % | p value | <50 % | ≥50 % | p value | <50 % | ≥50 % | p value | |
| All patients | 26 (50.9) | 25 (49.1) | 14 (36.8) | 24 (63.2) | 13 (38.2) | 21 (61.8) | |||
| Mean age, y (SD) | 47.5 (12.6) | 46.0 (11.5) | 0.65 | 50.7 (10.8) | 45.5 (11.6) | 0.18 | 49.2 (13.4) | 45.5 (11.0) | 0.39 |
| Tumor type | 0.82 | 0.27 | 0.84 | ||||||
| Astrocytoma | 15 (57.7) | 15 (60.0) | 8 (57.1) | 12 (50.0) | 7 (53.8) | 11 (52.4) | |||
| Oligoastrocytoma | 3 (11.5) | 4 (16.0) | 0 | 4 (16.7) | 1 (7.7) | 3 (14.3) | |||
| Oligodendroglioma | 8 (30.8) | 6 (24.0) | 6 (42.9) | 8 (33.3) | 5 (38.5) | 7 (33.3) | |||
| Other focal symptoms at diagnosis (n = 49) | 4 (16.0) | 9 (37.5) | 0.088 | 1 (7.7) | 6 (26.1) | 0.38 | 1 (3.5) | 5 (25.0) | 0.37 |
| Extent of surgery | 0.33 | 0.72 | 0.28 | ||||||
| Resection | 17 (65.4) | 13 (52.0) | 9 (64.3) | 14 (58.3) | 10 (76.9) | 11 (52.4) | |||
| Biopsy | 9 (34.6) | 12 (48.0) | 5 (35.7) | 10 (41.7) | 3 (23.1) | 10 (47.6) | |||
| Radiotherapy | 20 (76.9) | 16 (64.0) | 0.31 | 12 (85.7) | 14 (58.3) | 0.080 | 11 (84.6) | 12 (57.1) | 0.096 |
| Seizure classification | 0.12 | 0.94 | 0.64 | ||||||
| Partial | 12 (46.2) | 17 (68.0) | 8 (57.1) | 14 (58.3) | 7 (53.8) | 13 (61.9) | |||
| Generalized or both partial and generalized | 14 (53.8) | 8 (32.0) | 6 (42.9) | 10 (41.7) | 6 (46.2) | 8 (38.1) | |||
| Seizure frequency | 0.33 | 0.74 | 0.17 | ||||||
| >1/week | 17 (65.4) | 13 (52.0) | 8 (57.1) | 15 (62.5) | 6 (46.2) | 15 (71.4) | |||
| <1/week | 9 (34.6) | 12 (48.0) | 6 (42.9) | 9 (37.5) | 7 (53.8) | 6 (28.6) | |||
| AED polytherapy | 18 (69.2) | 15 (60.0) | 0.49 | 10 (71.4) | 16 (66.7) | 1.00 | 10 (76.9) | 14 (66.7) | 0.70 |
| Steroid use | 13 (50.0) | 12 (48.0) | 0.89 | 6 (42.9) | 9 (37.5) | 0.74 | 7 (53.8) | 6 (28.6) | 0.17 |