Table 1.
Slam receptor expression, associated effector molecules, and functions.
| Expression | Effectors | SAP-dependent | Eat2-dependent | Other/unknown | |
|---|---|---|---|---|---|
| SLAMF1, SLAM, CD150 | Act T, act B, mono, Mø, DC, plat, HSC | Fyn, Lck, SHIP-1, Src, Shp-1/2, PKCθ, Bcl-10, Beclin-1, PI3K, Nf-κB, Ras-GAP, Akt, JNK1/2, Dok-1/2 | T: (+) IL-4, IL-13, proliferation, Th2/Th17 polarization, NKT: development (with Slamf6) | Unknown | T: (+) IFNγ, B: (+) proliferation and activation, (+) apoptosis, Mø: (+) ROS, IL-12, TNFα, NO, (−) IL-6, (+) myeloid cell migration, (+) platelet aggregation, (+) phagocytosis |
| SLAMF2, CD48 | Pan-lymphocyte | Lck, Fyn, RhoA | N/A | N/A | T: (+) IL-2, proliferaton, B: (+) activation, (−) apoptosis Mast: (+) TNFα, eo: (+) activation, mobilization, Mø: (+) TNFα, IL-12, (+) phagocytosis, DC: (+) survival |
| SLAMF3, Ly-9, CD229 | T, B, iCD8, NKT, mono, Mø, HSC | AP-2, Grb-2, ERK, PLZF, NFAT | Unknown | Unknown | T: (−) IFNγ, (+) proliferation, IL-2, IL-4, iCD8+ T-cells, iNKT (−) development |
| SLAMF4, 2B4, CD244 | NK, NKT, T, γδ, CD8, DC, eo, mast, mono | LAT, PI3K, Vav-1, SHIP, c-Cbl, ERK, Shp-1/2, PLC-γ, 3BP2, Csk | T: (−) IFNγ, NK/CD8+: (+) cytotoxicity, proliferation | NK: (−) Cytotoxicity of Slamf2-neg target cells, (−) IFNγ | eo: (+) adhesion, chemotaxis, peroxidase, (+) IFNγ, IL-4 |
| SLAMF5, CD84 | Pan-lymphocyte plat, mast, eo | Dok-1, c-Cbl, ERK, JNK, Fes, Shp-1, Nf-κB | T-B: (+) GC response | NK: (+) Cytotoxicity Mast: (+) Degranulation | lat: (+) spreading |
| SLAMF6, NTB-A, Ly-108 | NK, NKT, T, B, Mø, pDC | PLC-γ, SHIP, Shp-1/2, PI3K, PLZF, Lck, PKCθ, NFAT | T-B: (+) GC response, NK: (+) IFNγ, NKT: development (with Slamf1) | NK: (+) Cytotoxicity | T-B: (−) GC response, Neutro: (+) ROS, (+) IL-6, TNFα |
| SLAMF7, CRACC, CS1, CD319 | T, B, mono, DC, NK | PLC-γ, c-Cbl, SHIP, Akt, Vav-1, Shp-1/2 | Unknown/N/A | NK: (+) Cytotoxicity | NK: without Eat2 (−) Cytotoxicity, B: (+) proliferation |
| SLAMF8, BLAME | iCD8, mono, DC, Mø, Neu, endo, FRC | PKC, p40(phox) | N/A | N/A | (−) myeloid cell migration, (−) ROS, iCD8+ T-cells, iNKT (+) development |
| SLAMF9, SF2001 | mono, DC | ND | N/A | N/A | Unknown |
T, T cells; B, B cells; act, activated; Mø, macrophage; DC, dendritic cell; plat, platelet; HSC, hematopoietic stem cell; mono, monocyte; NKT, natural killer T cell; eo, eosinophil; γδ, γδ receptor-expressing T cell; mast, mast cell; endo, endothelial cell; FRC, fibroblastic reticular cell; ROS, reactive oxygen species.
Expression data are based on murine expression.