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Validation of Selected Genes In Vivo in the RAG2 KO Mouse Model
| Summary of Individual shRNA knock down (KD) Data | |
|---|---|
| Treatment Arm | Tumor Take Rate |
| Untreated | 6/6 |
| Empty vector (pLKO) | 6/8 |
| CAIX-shRNA1 | 0/8 |
| CAIX-shRNA2 | 0/8 |
| MCT4-shRNA1 | 0/8 |
| MCT4-shRNA2 | 0/8 |
| xCT-shRNA1 | 0/8 |
| xCT-shRNA2 | 0/8 |
Tumor take rate of the primary pancreatic tumor cells (PDX15) expressing shRNAs targeting CAIX (shRNA1 and shRNA2), xCT (shRNA1 and shRNA2), MCT4 (shRNA1 and shRNA2), empty vector (pLKO), and untreated control.
