Figure 1.
Clemastine rescues social avoidance behavior in socially isolated mice. A, Experimental scheme. Adult mice were group-housed for 10 weeks or isolated for 8 weeks followed by daily treatment of vehicle (ddH2O) or clemastine (gastric gavage, 10 mg kg−1 body weight) for 2 weeks. Mice were tested for social interaction behavior at the end of 10 weeks. B, Clemastine (clem) did not affect locomotor activity of socially isolated mice. C, Clemastine rescued time spent with a conspecific mouse of socially isolated mice [n = 25 for group-housed (group), n = 21 for iso+veh, n = 19 for iso+clem]. ***p < 0.001 by one-way ANOVA followed by Tukey's post hoc test. n.s., Not significant. Data are mean ± SEM.