Fig. 6.

Bone histomorphometry performed on femurs from 1-mo-old Dmp1-Cre^+/−;Rosa^Notch female mice in an Rbpjκ intact background (Notch, dark grey boxes) or in the context of the Rbpjκ deletion, Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ, (Notch;Rbpjκ^Δ/Δ, light gray boxes) and control Rosa^Notch (control, open boxes) mice. Trabecular bone histomorphometric parameters: BA/TA, Tb.N, OcS/BS, NOc/BPm, ES/BS, ObS/BS, and NOb/BPm. Dmp1-Cre^+/−;Rosa^Notch and Rosa^Notch control mice shown were obtained from litters pooled over an ∼4-yr period and included Dmp1-Cre^+/−;Rosa^Notch matched to Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ littermate mice; n = 3–14. Horizontal continuous lines represent the median and interrupted lines represent the mean; upper and lower limits of the box represent 75^th and 25^th percentiles. Whiskers (bars) indicate maximum and minimum values. *Significantly different from controls; #Significantly different between Dmp1-Cre^+/−;Rosa^Notch and Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ, by Kruskal-Wallis test, P < 0.05. Representative histological femoral sections from 1-mo-old Dmp1-Cre^+/−;Rosa^Notch (Notch), Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ (Notch;Rbpjκ^Δ/Δ), and Rosa^Notch controls are shown on the bottom. Sections were stained with toluidine blue; final magnification ×40 and ×630. Arrows point to osteoclasts on trabecular surfaces.