Fig. 8.

Notch1 Nicd, Rbpjκ, Hey1, Hey2, HeyL, Tnfsrf11b, Tnfsf11, Sost, Dkk1 and Axin2 mRNA levels in tibiae of 1-mo-old Dmp1-Cre^+/−;Rosa^Notch mice in an Rbpjκ intact background (Notch, dark gray boxes) or in the context of Rbpjκ deletion, Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ (Notch;Rbpjκ^Δ/Δ, light gray boxes), and control Rosa^Notch (control, open boxes) mice. mRNA levels obtained from Rosa^Notch control and Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ were compared with littermate-matched Dmp1-Cre^+/−;Rosa^Notch mice. To compare the 3 groups, mRNA levels from Dmp1-Cre^+/−;Rosa^Notch mice were normalized to 1. Data from Dmp1-Cre^+/−;Rosa^Notch and Rosa^Notch control littermate mice were obtained from litters pooled over an ∼4-yr period and included Dmp1-Cre^+/−;Rosa^Notch matched to Dmp1-Cre^+/−;Rosa^Notch;Rbpjκ^Δ/Δ littermate mice; n = 3–7. Horizontal continuous lines represent the median and interrupted lines represent the mean; upper and lower limits of the box represent 75^th and 25^th percentiles. Whiskers (bars) indicate maximum and minimum values. *Significantly different from controls; by Kruskal-Wallis test, P < 0.05.