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. 2015 Oct 21;310(2):C99–C114. doi: 10.1152/ajpcell.00092.2015

Fig. 5.

Fig. 5.

Effect of P2X and P2Y inhibitors on ATP-induced changes of [Ca2+]cyt and intracellular Ca2+ changes induced by P2X and P2Y activators. A: representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM ATP in normal and lung cancer cells (n = 4–14) (left); representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM ATP in the present of 10 μM PPADS in normal and lung cancer cells (n = 4–5) (middle); representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM ATP in the present of 100 nM TNP-ATP in normal and lung cancer cells (n = 3) (right). B: representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM β,γ-meATP in normal and lung cancer cells (n = 3) (left); representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM α,β-meATP in normal and lung cancer cells (n = 3) (right). C: representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM ATP in the presence of 10 μM U-73122 in normal and lung cancer cells (n = 3) (left); representative traces showing changes in [Ca2+]cyt before, during, and after application of 100 μM UTP (n = 3) (right).