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Silencing PPP2R2C increases Akt activity and proinflammatory factors. A and B: mouse RPTCs were transfected with NS siRNA and PPP2R2C siRNA. Protein expressions of D2R, Akt, p-Akt, GSK3β, p-GSK3β, and cyclin D1 (A) and TNF-α, MCP-1, and IL-6 (B) were quantified by immunoblotting. Inset: 1 set of immunnoblots Results are expressed as percentage of NS siRNA. *P < 0.05 vs. NS siRNA; n = 5/group.
