Fig. 4.

LY-2584702 prevents TGF-α-induced pulmonary fibrosis. CCSP/TGF-α mice were administered Dox for 4 wk to induce pulmonary fibrosis and treated with vehicle or LY-2584702 (25 mg/kg, 2 times/day). A: representative photomicrographs of lung tissues stained with Masson trichrome staining. Panel on top centers on the peribronchial and perivascular areas and the panel on bottom the subpleural regions of the lung. B: morphometric quantification of the subpleural thickness measured from lung sections. C: total lung collagen of right lung measured with hydroxyproline. Data are means ± SE (n = 8–11 mice in each group), and statistical differences shown were performed using ANOVA.