Fig. 6.

LY-2584702 inhibition as a rescue therapy minimally alters the progression of established pulmonary fibrosis. CCSP/TGF-α mice were administered Dox for 8 wk; 5 wk into Dox, mice were treated with either vehicle or LY-2584702 (25 mg/kg, 2 times/day). A: changes in body weight of CCSP/− controls and CCSP/TGF-α mice treated with either vehicle or LY-2584702. “X” represent mouse deaths in CCSP/TGF-α mice treated with either vehicle (red) or LY-2584702 (green). B: representative low-power photomicrographs of lung tissues stained with Masson trichrome staining. C: morphometric quantification of the subpleural thickness measured from lung sections. D: total lung collagen of the right lung measured with hydroxyproline. Data are means ± SE (n = 8–22 mice in each group), and statistical differences shown were performed using ANOVA.