Table 1.

Gene Expression Profiles for Aging

A. 1254 Age-Regulated Genes Are Enriched for Intestine and Oocyte Genes
Data Set	# of Genes	Overlap	Representation Factora	p Valueb
Intestine enriched genesc	609	143	3.3	5.612 × 10−39
Oocyte enriched genesd	258	28	2.1	2 × 10−4
Muscle enriched genese	230	15	0.9	<0.424
Pharynx enriched genesf	194	0	0	N/A
Neuronal enriched genese	85	0	0	N/A

B. A GATA Regulatory Motif Is Highly Enriched in the Promoters of Age-Regulated Genes
Data Set	# of Genes	Rk (p Value)	GATA Motif	GATA Enrichment (p Value)
Aging time courseg	180	0.429 (p < 10−20)		0.009
Dauer/normalh	478	0.301 (p < 10−20)		8 × 10−5
age-1/wt	758	0.048 (p = 0.037)		3 × 10−5
daf-2; daf-16/daf-2i	214	−0.369 (p < 10−29)		3 × 10−3
daf-16/wt	886	−0.247 (p < 10−29)		1 × 10−06
Data Set	# of Genes	Overlap (p Value)	GATA Motif	GATA Enrichment (p value)
daf-16/wt (class1 and 1)j	467	127 (p < 0.0001)		5 × 10−9

^aThe representation factor is the number of overlapping genes divided by the expected number expected by chance.

^bHypergeometric p value.

^cPauli et al., 2006;

^dReinke et al., 2000;

^eRoy et al., 2002;

^fGaudet and Mango, 2002;

^gLund et al., 2002;

^hWang and Kim, 2003;

ⁱMcElwee et al., 2004;

^jMurphy et al., 2003.

^kPearson Correlation Coefficient comparing the set of genes in the list to the set of 1254 age-regulated genes.