Table 2.
Effect of low-dose dopamine infusion on circulating plasma catecholamines
Saline | 1 μg·kg−1·min−1 | 2 μg·kg−1·min−1 | 3 μg·kg−1·min−1 | 4 μg·kg−1·min−1 | Effect of Dose | |
---|---|---|---|---|---|---|
Norepinephrine, pg/ml | ||||||
All | 230 ± 21 | 225 ± 20 | 219 ± 16 | 225 ± 17 | 220 ± 16 | 0.986 |
High HVR | 225 ± 37 | 212 ± 29 | 227 ± 18 | 201 ± 18 | 242 ± 31 | 0.804 |
Low HVR | 234 ± 25 | 233 ± 28 | 213 ± 24 | 242 ± 25 | 204 ± 18 | 0.413 |
Epinephrine, pg/ml | ||||||
All | 26 ± 6 | 31 ± 10 | 27 ± 9 | 32 ± 9 | 32 ± 12 | 0.744 |
High HVR | 25 ± 9 | 25 ± 6 | 19 ± 2 | 30 ± 7 | 24 ± 6 | 0.608 |
Low HVR | 28 ± 9 | 34 ± 16 | 33 ± 15 | 33 ± 15 | 38 ± 19 | 0.661 |
Dopamine, pg/ml | ||||||
All | 21 ± 6 | 4430 ± 500* | 12145 ± 1390*† | 19576 ± 1875*†‡ | 28956 ± 2149*†‡§ | <0.001 |
High HVR | 18 ± 5 | 4822 ± 791* | 11098 ± 1388*† | 21171 ± 2406*†‡ | 31633 ± 2828*†‡§ | <0.001 |
Low HVR | 23 ± 10 | 4125 ± 664 | 12960 ± 2264*† | 18336 ± 2812*†‡ | 26874 ± 3080*†‡§ | <0.001 |
Data reported as means ± SE. Norepinephrine (all n = 17; high HVR n = 7; low HVR n = 10), epinephrine (all n = 10; high HVR n = 4; low HVR n = 6), and dopamine (all n = 16; high HVR n = 7; low HVR n = 9). HVR, hypoxic ventilatory response.
P < 0.05 vs. saline,
P < 0.05 vs. 1 μg·kg−1·min−1,
P < 0.05 vs. 2 μg·kg−1·min−1,
P < 0.05 vs. 3 μg·kg−1·min−1.
Numbers in bold represent statistical significance.