(A) Average maps (aligned to soma, white circle) of connection probability for inhibitory inputs in NR (left) and DE (right) animals. Connection probability is encoded in pseudocolor. White horizontal lines indicate averaged laminar borders and are 200 μm long. Traces in the center show the laminar marginal distributions (red for NR and black for DE). Traces at the bottom of the DE panel indicate the columnar marginal distributions. Note that NR and DE maps and distributions appear different.
(B) Average maps (aligned to soma, white circle) of connection strength (transferred charge) for inhibitory connections in NR (left) and DE (right) animals. Averages are only calculated for stimulation sites that evoked responses in >10% of cells in our sample. Connection strength is encoded in pseudocolor. White horizontal lines indicate averaged laminar borders and are 200 μm long. Traces in the center show the laminar marginal distributions (red for NR and black for DE). Traces at the bottom of the DE panel indicate the columnar marginal distributions. Note that NR and DE maps and distributions appear different.
(C) Distributions of area of input (left), total IPSC input amplitude (center), and total IPSC input charge (right) originating from L2/3 (top), L4 (middle), and L5/6 (bottom) of NR (red) or DE (black) animals. Significance: * denotes p < 0.05; ** denotes p < 0.01. IPSC area distributions: L2/3: p = 0.000324; L4: p = 0.00969; L5/6: p = 0.020. Total IPSC amplitude distributions: L2/3: p = 0.000663; L4: p = 0.0137; L5/6: p = 0.0234. Total IPSC charge distributions: L2/3: 0.00172; L4: 0.0303; L5/6: 0.0191. All comparisons were done with a KS test.
(D) Distributions of IPSC amplitude (left) and IPSC charge (right) originating from L2/3 (top), L4 (middle), and L5/6 (bottom) of NR (red) or DE (black) animals. All p > 0.05. Average IPSC amplitude distribution: L2/3: p = 0.850; L4: p = 0.105; L5/6: p = 0.559. Average IPSC charge: L2/3: p = 0.816; L4: p = 0.710; L5/6: p = 0.854. All comparisons were performed with a KS test.