Table 1.
Activity of Precatalyst 1 in Reactions Selected from the Literature
| entry | reactiona | yield w/ precatalyst 1 | literature precatalyst (literature yield) |
|---|---|---|---|
| 1 |
|
98% yield (87% yield)b |
 (96% yield) ref 14a |
| 2 |
|
96% yield | [(dppf)Ni(cinnamyl)Cl] (91% yield) ref 9 |
| 3 |
|
43% yield | Ni(cod)2 PPh3 (68% yield) ref 20 |
| 4 |
|
98% yield | Ni(cod)2 PCy3 (93% yield) ref 21 |
| 5 |
|
80% yield | Ni(cod)2 bathophen (67% yield) ref 22 |
| 6c |
|
83% yield | [(dppf)Ni(o-tolyl)Cl] (85% yield) ref 11 |
| 7 |
|
79% yield | Ni(cod)2 PCy3 (88% yield) ref 23 |
| 8 |
|
65% yield | Ni(cod)2 SIPr (95% yield) ref 24 |
| 9 |
|
86% yield | Ni(cod)2 IPr (98% yield) ref 25 |
a
The scale and concentrations were identical to the original report. See the Supporting Information for full details.
b
This reaction was also run on 4 mmol (~1 g) scale.
c
Entry 6 was run without K3PO4 as this was empirically found to result in higher yield.