Table 3.

Odds for severe cognitive decline according to comorbidity status.

	Model One		Model Two		Model Three
Comorbidity Status	OR	95% CI	OR	95% CI	OR	95% CI
Time	**1.13	1.11 – 1.16	**1.14	1.12 – 1.17	**1.15	1.12 – 1.18
No depression, no diabetes (ref)	~	~	~	~	~	~
Depression, no diabetes	0.99	0.70 – 1.41	0.95	0.67 – 1.36	1.01	0.71 – 1.44
Diabetes, no depression	0.83	0.58 – 1.19	0.79	0.55 – 1.13	0.77	0.53 – 1.12
Depression and diabetes	0.91	0.55 – 1.52	0.82	0.49 – 1.36	0.83	0.48 – 1.41
Comorbidity status x time
No depression, no diabetes (ref)	~	~	~	~	~	~
Depression, no diabetes	1.02	0.97 – 1.06	1.01	0.97 – 1.06	1.01	0.96 – 1.06
Diabetes, no depression	**1.07	1.03 – 1.12	**1.08	1.03 – 1.12	**1.08	1.03 – 1.13
Depression and diabetes	*1.08	1.01 – 1.15	*1.08	1.03 – 1.12	1.07	0.99 – 1.15

Model one controlled for age, educational attainment, baseline MMSE, and time (years) of follow-up.

Model two included the covariates from model one plus nativity, smoking status, alcohol consumption status, marital status, number of residents living in the home, hypertension, heart disease, stroke, ability to perform ADLs and IADLs, and language.

Model three included the covariates from model two, but excluded participants with baseline MMSE ≤ 17.

^*Statistical significance P < 0.05;

^**Statistical significance P < 0.01.

Coefficient estimates were exponentiated to be interpreted as odds ratios.

OR (Odds Ratio); CI (Confidence Interval)