Table 2.
Noncompartment model pharmacokinetic parameters of the three compounds after oral administration with extracts (n = 6)
| Compounds | Pharmacokinetic parameters | TP | TP-TF co-decoction | TP-TF mixed decoction |
|---|---|---|---|---|
| Typhaneoside | Cmax (ng/mL) | 76.39 ± 53.21 | 370.86 ± 315.71* | 214.32 ± 73.72** |
| Tmax (h) | 2.95 ± 2.88 | 0.24 ± 0.15* | 0.21 ± 0.08 | |
| T1/2 (h) | 3.35 ± 2.58 | 1.91 ± 1.26 | 1.37 ± 0.54 | |
| AUC0~t (ng/h/mL) | 268.31 ± 167.71 | 333.46 ± 191.84 | 275.62 ± 206.06 | |
| Vanillic acid | Cmax (ng/mL) | 2211.68 ± 1187.17 | 3870.99 ± 2527.99 | 1447.29 ± 500.99 |
| Tmax (h) | 1.25 ± 0.71 | 1.47 ± 3.20 | 0.17 ± 0.09** | |
| T1/2 (h) | 3.69 ± 0.87 | 11.25 ± 13.61 | 8.88 ± 3.76 | |
| AUC0~t (ng/h/mL) | 10445.53 ± 4148.68 | 14137.57 ± 4540.37 | 6193.78 ± 4499.17 | |
| P-coumaric acid | Cmax (ng/mL) | 4901.39 ± 1887.30 | 5110.22 ± 3671.26 | 4189.45 ± 844.37 |
| Tmax (h) | 1.08 ± 1.67 | 1.42 ± 1.39 | 0.46 ± 0.40 | |
| T1/2 (h) | 3.67 ± 1.82 | 10.08 ± 7.86 | 10.08 ± 10.23 | |
| AUC0~t (ng/h/mL) | 36881.01 ± 25783.25 | 41512.56 ± 41763.28 | 17689.11 ± 3882.21 |
* P < 0.05,** P < 0.01versus TP sole administration