Table 4.
Analysis of associations between ME/CFS symptoms and mtDNA SNPs
| Nucleotide position | Symptomatic allele | p value | q value* | Symptom | Type | Survey |
|---|---|---|---|---|---|---|
| 150 | T | 0.000196 | 0.01373 | Accomplished less emotional | – | SF-36 |
| 150 | T | 0.000308 | 0.02156 | Emotional limitations | – | SF-36 |
| 150 | T | 8.94E-05 | 0.005944 | Less time for work | – | SF-36 |
| 150 | T | 0.00048 | 0.03358 | Didn’t work as carefully | – | SF-36 |
| 930 | G | 9.71E-05 | 0.006795 | Difficulty performing work | – | SF-36 |
| 1719 | A | 3.80E-06 | 0.0002661 | Inflammatory distress | Cluster | DePaul |
| 1719 | A | 4.17E-05 | 0.002919 | Flu-like symptoms | Distress | DePaul |
| 1719 | A | 6.09E-05 | 0.004262 | Chemical sensitivity | Distress | DePaul |
| 1719 | A | 6.54E-05 | 0.00458 | Neuro inflammatory distress | Cluster | DePaul |
| 1719 | A | 0.000161 | 0.01129 | Sensitivity to bright lights | Distress | DePaul |
| 1719 | A | 0.000295 | 0.02068 | Chemical sensitivity | Severity | DePaul |
| 1719 | A | 0.000301 | 0.02108 | Sensitivity to bright lights | Frequency | DePaul |
| 3010 | A | 0.000173 | 0.01208 | Sleep in day, awake all night | Frequency | DePaul |
| 3010 | A | 0.000226 | 0.01582 | Sleep in day, awake all night | Distress | DePaul |
| 5147 | G | 0.001175 | 0.04114 | Difficulty performing work | – | SF-36 |
| 16093 | T | 0.000206 | 0.0144 | Accomplished less physical | – | SF-36 |
| 16093 | T | 0.000289 | 0.02022 | Physical limitations | – | SF-36 |
| 16223 | T | 0.00076 | 0.0266 | Sensitivity to bright lights | Frequency | DePaul |
| 16223 | T | 0.000885 | 0.03098 | Neuro inflammatory distress | Cluster | DePaul |
| 16519 | C | 0.000125 | 0.008729 | Gastrointestinal distress | Cluster | DePaul |
| 16519 | C | 0.000135 | 0.009423 | Bloating | Severity | DePaul |
| 16519 | C | 0.000149 | 0.01043 | Abdomen/stomach pain | Severity | DePaul |
| 16519 | C | 0.000182 | 0.01274 | Bloating | Frequency | DePaul |
| 16519 | C | 0.000355 | 0.02482 | Bloating | Distress | DePaul |
*q values were calculated by the Benjamini–Hochberg correction applied to the number of SNPs included in the association test for each symptom
Chemical sensitivity refers to “Some smells, foods, medications, or chemicals make you feel sick”. The neuro inflammatory distress cluster combines “sensitivity to bright lights” and ”sensitivity to noise.” The inflammatory distress cluster combines these symptoms: sore throat, tender/sore lymph nodes, fever, flu-like symptoms, and chemical sensitivity. The gastrointestinal distress cluster combines bloating, abdomen/stomach pain, irritable bowel, and nausea. Subjects indicated whether they accomplished less due to emotional factors or because of physical limitations