Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Novel two independent pathways for mitochondrial quality control induced by proteasome defects. Cells lacking Fzo1 show poor growth, low mitochondrial membrane potential (ΔΨm), and defects in mitochondrial fusion (bottom). Proteasome defects increase Mia40 (left pathway) and the s-Mgm1/l-Mgm1 ratio (right pathway) in fzo1Δ cells. Increased Mia40 restores poor growth and mitochondrial membrane potential. Increase of the s-Mgm1/l-Mgm1 ratio induces Fzo1-independent mitochondrial fusion.
