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Human telomerase RNA circular permutations reveal structure-function correlations. The sequence of the 451-nucleotide hTR is depicted. The dashed line between positions 1 and 451 indicates the joined ends in the circular permutants. Each circular permutation allele phenotype is indicated by an arrow pointing to the location of the repositioned 5′ and 3′ ends. The color of the arrow represents the relative activity bin.
