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. 2016 Jan 4;36(2):271–284. doi: 10.1128/MCB.00868-15

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FIG 3 — Keap1^C273W&C288E represses Nrf2 activity in vivo. (A) A schematic presentation of KRD-Keap1^C273W&C288E transgene that expresses Keap1 under the regulation of KRD is shown. (B) Growth curves for Keap1^−/−, Keap1^−/−::Tg-Keap1^WT mice (line 34) and Keap1^−/−::Tg-Keap1^C273W&C288E mice (line 30). Note that mice of the last two genotypes grew normally. (C to F) Hematoxylin-eosin staining of esophagus transverse sections of Keap1^+/− (C), Keap1^−/− (D), Keap1^−/−::Tg-Keap1^WT (E), and Keap1^−/−::Tg-Keap1^C273W&C288E (F) mice at P10. The arrow in panel D indicates the thickened cornified layer. (G to J) Nrf2 immunostaining of esophagus transverse sections of Keap1^+/− (G), Keap1^−/− (H), Keap1^−/−::Tg-Keap1^WT (I), and Keap1^−/−::Tg-Keap1^C273W&C288E (J) mice at P10. Arrowheads indicate Nrf2 accumulation in basal layer cells of esophagi.