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Depletion of NRF2 or MED16 results in vulnerability to oxidative stress. (A) Relative viabilities of WT and Nrf2 knockdown Hepa1c1c7 cells after 24 h of treatment with menadione. Two different Nrf2 shRNAs (1 and 2) were used. (B) Relative viabilities of WT and Med16 KO Hepa1c1c7 cells after 24 h of treatment with menadione. Two independent clones of Med16 KO cells (1 and 2) were examined. Error bars show standard deviations. ***, P < 1 × 10−4.
