Table 5.

Association between the investigated genotypes and FVC% predicted in SSc patients in the discovery cohort

		FVC%		FVC% (adjusted for ATA status)
SNP (Coded allele)	Gene	β (95 % CI)	p value	β (95 % CI)	p value
rs2736100 (T)*	TERT	0.51 (-1.04; 2.05)	0.521	0.76 (-0.81; 2.34)	0.343
rs2076295 (G) *	DSP	−2.29 (-3.85; -0.74)	0.004	−2.52 (-4.09; -0.95)	0.002
rs4727443 (A)*	AZGP1	−0.27 (-1.85; 1.32)	0.742	0.08 (-1.53; 1.70)	0.919
rs7934606 (A)*	MUC2	−0.55 (-2.16; 1.05)	0.499	−0.75 (-2.37; 0.86)	0.360
rs2034650 (C)*	IVD	0.67 (-0.90; 2.25)	0.402	0.37 (-1.22; 1.97)	0.646
rs1981997 (A) *	MAPT	2.26 (0.35; 4.17)	0.020	3.19 (1.23; 5.14)	0.001
rs12610495 (G)*	DPP9	0.57 (-1.18; 2.32)	0.523	1.05 (-0.72; 2.82)	0.246
rs6793295 (C)*	LRRC34	−0.46 (-2.19;1.27)	0.599	−1.05 (-2.82; 0.71)	0.242
rs2609255 (G)*	FAMI3A	1.72 (-0.10; 3.55)	0.064	1.61 (-0.18; 3.41)	0.079
rs11191865 (G)*	OBFC1	−0.73 (-2.27; 0.82)	0.356	0.02 (-1.55; 1.60)	0.977
rs1278769 (A)*	ATP11A	−0.62 (-2.45; 1.20)	0.503	−0.74 (-2.60; 1.11)	0.433
rs1379326 (G)†	CSMD1	3.35 (-0.84; 7.54)	0.117	3.12 (-1.08; 7.31)	0.145
rs17690703 (T) *	SPPL2C	2.04 (0.21; 3.88)	0.029	2.11 (0.30; 3.91)	0.022

Gene names: TERT: telomerase reverse transcriptase; DSP: desmoplakin; AZGP1: alpha-2-glycoprotein 1, zinc-binding; MUC2: mucin 2; IVD: isovaleryl-CoA dehydrogenase; MAPT: microtubule-associated protein tau; DPP9: dipeptidyl-peptidase 9; LRRC34: leucine-rich repeat-containing 34; FAMI3A: family with sequence similarity 13, member A; OBFC1: oligonucleotide/oligosaccharide-binding fold containing 1; ATP11A: ATPase, class VI, type 11A; CSMD1: CUB and Sushi multiple domains 1; SPPL2C: signal peptide peptidase-like 2C

FVC% percent predicted forced vital capacity, SSc systemic sclerosis, ATA anti-topoisomerase 1 antibody, SNP single nucleotide polymorphism

^*Additive model; ^†Recessive model