Table 1.

Summary of contributing immunological factors in ASC

Level of biological processes	Immunological factors involved
Genetic	IFN-γ, Toll-like receptors, T-cell receptor
Extracellular mediators	Maternal antibodies, cytokines and chemokines
Cell surface proteins	Human leukocyte antigen, Toll-like receptors
Intracellular signalling	mTOR, PTEN, NF-κB
Neural changes	Neuron density, glial proliferation