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Direct-contact transmission of H4 avian influenza viruses in guinea pigs. Groups of three guinea pigs were inoculated i.n. with 106.0 EID50 of test virus. Twenty-four hours later, three naive guinea pigs were introduced into the same cage. Nasal washes were collected at 2-day intervals. Each color bar represents the virus titer from an individual animal. The horizontal dashed red lines indicate the lower limit of detection.
