FIG 6.

Correlations between HLA allele features and relative spread of associated polymorphisms. (A) No significant correlation between the population HLA allele frequency and the median fold increase in its associated HIV-1 polymorphisms between the historic and modern eras was observed. (B) A significant inverse correlation between the HR-AIDS of an HLA allele and the median fold increase of its associated HIV-1 polymorphisms between eras was observed. Individuals with known/suspected early infection were excluded from the analysis.