FIG 2.

VP1 of HPeV-1 does not contain a hydrophobic pocket. The VP1 proteins of HPeV-1 (A) and poliovirus type 1 (B) are shown as cartoon representations. The pocket factor in poliovirus type 1 is shown as a stick model in orange. The side chains of residues that interact with the pocket factor are also shown as sticks. In panel A, the poliovirus type 1 pocket factor was superimposed onto the HPeV-1 structure. However, the pocket is not formed, and the side chains of several residues clash with the pocket factor.