Table 1.
Baseline characteristics according to serum irisin tertile
| Total (n = 424) | 1st tertile (n = 142) | 2nd tertile (n = 141) | 3rd tertile (n = 141) | P | |
|---|---|---|---|---|---|
| Irisin (μg/mL) | 1.71 (1.44, 2.02) | 1.35 (1.20, 1.45) | 1.72 (1.62, 1.81) | 2.30 (2.04, 2.68) | <0.001 |
| Age (year) | 47.1 (9.2) | 48.7 (8.5)a | 47.5 (8.7)ab | 45.2 (10.0)b | 0.005 |
| Male (%) | 233 (55.0) | 88 (62.0) | 71 (50.4) | 74 (52.3) | 0.11 |
| Body mass index (kg/m2) | 24.7 (3.5) | 25.1 (2.9) | 24.6 (3.9) | 24.3 (3.6) | 0.15 |
| Waist circumference (cm) | 84.3 (9.7) | 85.8 (7.7)a | 84.2 (10.7)ab | 82.9 (10.4)b | 0.041 |
| Systolic blood pressure (mmHg) | 121.3 (14.1) | 123.1 (14.1) | 120.6 (14.1) | 120.1 (14.0) | 0.18 |
| Diastolic blood pressure (mmHg) | 75.8 (10.2) | 77.0 (10.8) | 76.4 (9.7) | 74.1 (9.8) | 0.05 |
| OGTT (mmol/L) | |||||
| 0 min | 6.4 (1.9) | 6.7 (2.0) | 6.3 (1.5) | 6.3 (2.0) | 0.13 |
| 120 min | 8.6 (3.8) | 8.8 (4.1)ab | 8.0 (2.7)a | 9.3 (4.4)b | 0.041 |
| A1c (%) | 6.0 (1.3) | 6.0 (1.1) | 5.9 (1.0) | 6.2 (1.6) | 0.06 |
| HOMA-IR | 2.26 (1.61, 3.24) | 2.50 (1.83, 3.26)a | 2.30 (1.79, 3.23)a | 1.90 (1.25, 3.40) | 0.001 |
| HOMA-B (%) | 73.2 (52.4, 97.2) | 74.2 (52.3, 99.1) | 74.4 (54.7, 98.0) | 72.2 (46.9, 92.9) | 0.47 |
| Type 2 diabetes (%) | 92 (21.7) | 30 (21.1) | 29 (20.6) | 34 (24.1) | 0.54 |
| Pre-diabetes/type 2 diabetes (%) | 333 (785) | 129 (90.8) | 118 (83.7) | 86 (61.0) | <0.001 |
| Total cholesterol (mmol/L) | 4.96 (0.90) | 5.11 (0.85)a | 5.00 (0.86)ab | 4.77 (0.96)b | 0.005 |
| Triglyceride (mmol/L) | 1.74 (1.25, 2.59) | 1.45 (1.01, 2.26)a | 1.25 (0.98, 1.70)a | 1.08 (0.76, 1.44) | <0.001 |
| HDL cholesterol (mmol/L) | 1.31 (0.32) | 1.27 (0.27) | 1.34 (0.37) | 1.34 (0.29) | 0.09 |
| LDL cholesterol (mmol/L) | 3.03 (0.85) | 3.11 (0.81) | 3.05 (0.81) | 2.93 (0.93) | 0.22 |
| High-sensitivity CRP (mg/L) | 0.04 (0.02, 0.11) | 0.04 (0.02, 0.09) | 0.04 (0.02, 0.11) | 0.05 (0.03, 0.11) | 0.07 |
| Metabolic syndrome (%) | 155/414 (37.4) | 59/137 (43.1) | 54/138 (39.1) | 42/139 (30.2) | 0.027 |
Data are expressed as means ± SDs, medians ± inter-quartile ranges or frequency (%)
a,bThe same letters indicate no statistical significance