Table 1.
Effects of I3C and Sil, alone and in combination, against NNK-induced and LPS-enhanced lung tumors in A/J micea
| Treatment group |
Chemopreventive agent |
Mice number Initially/at termination |
Lung tumors/mouse |
|---|---|---|---|
| None | None | 10/10 | 0.1 ± 0.3 |
| LPS | None | 10/10 | 0.2 ± 0.2 |
| NNK | None | 15/15 | 4.8 ± 3.8 |
| NNK + LPS | None | 20/17 | 14.7 ± 4.1 |
| NNK + LPS | I3C | 20/20 | 15.0 ± 11.1 |
| NNK + LPS | Sil | 20/18 | 12.5 ± 5.2 |
| NNK + LPS | I3C + Sil | 20/20 | 7.1 ± 4.5b |
a
Beginning at age 6–7 weeks, groups of female A/J mice received NNK (100 mg/kg) by intraperitoneal injection. LPS was administered, once a week, by intranasal instillation (2 µg/mouse in 50 µl physiological saline solution, 25 µl in each nostril) throughout the study. I3C and Sil were given in the diet at a concentration of 20 µmol/g beginning two weeks after NNK administration until the termination of the study.
b
Significant compared with group 1 (p < 0.05).