Table 5.

Physical characteristics of metformin hydrochloride matrix tablets prepared by direct compression.

Formulation	Weight (mg)	Thickness (mm)	Crushing strength (N)	Friability (%)	CSFR	Drug content (%)
M1	619.2 ± 20.0	6.92 ± 0.12	65.9 ± 21.3	1.30	50.69	106.64 ± 2.73
M2	627.4 ± 17.2	6.73 ± 0.16	136.5 ± 21.6	0.47	290.43	96.24 ± 2.55
M3	601.7 ± 16.0	7.05 ± 0.17	41.0 ± 10.0	2.71	15.13	96.38 ± 1.78
M4	598.8 ± 15.3	6.68 ± 0.33	193.0 ± 38.1	0.70	275.71	90.12 ± 3.20
M5	602.2 ± 18.1	7.13 ± 0.32	65.3 ± 33.6	1.34	48.73	96.18 ± 1.94
M6	596.2 ± 10.0	7.06 ± 0.04	128.7 ± 17.7	0.64	201.09	99.15 ± 3.38
M7	612.6 ± 9.7	7.31 ± 0.06	32.7 ± 8.6	3.23	10.12	103.29 ± 2.94
M8	616.8 ± 16.9	6.66 ± 0.04	97.5 ± 18.2	0.75	130.00	104.68 ± 1.78
M9	602.2 ± 8.7	6.41 ± 0.09	180.3 ± 18.1	0.67	269.10	105.17 ± 4.23
M10	595.3 ± 7.8	6.68 ± 0.02	80.4 ± 18.7	0.46	174.78	99.27 ± 2.56
M11	600.0 ± 10.1	6.83 ± 0.20	139.6 ± 20.3	0.61	228.85	106.35 ± 2.44
M12	620.4 ± 9.0	7.11 ± 0.14	56.4 ± 21.7	0.84	67.14	109.30 ± 1.98
M13	615.8 ± 15.3	6.93 ± 0.22	51.9 ± 31.3	2.72	19.08	102.93 ± 3.26