Table 1.
HP1γ interacting proteins function in the DNA damage response
| Description | Accession No. | M. W. (kDa) | Unique spectral count |
Significance validation |
|||||
|---|---|---|---|---|---|---|---|---|---|
| G1-S | M | Empty | Fold ratio (G1-S or M/control) | GO | Article references | Co-IP Ex. | |||
| Bloom syndrome protein (BLM) | IPI00004859 | 159 | 2 | 1 | 0 | O | O | - | O |
| Chromobox protein homolog 3 (CBX3, the bait in this study) | IPI00297579 | 21 | 57 | 63 | 4 | O | O | - | Not done |
| Isoform 1 of Replication protein A 32 kDa subunit (RPA2) | IPI00013939 (+2) | 29 | 6 | 7 | 4 | O | O | - | Not done |
| Isoform 2 of AT-rich interactive domain-containing protein 1A (ARID1A) | IPI00642705 (+2) | 218 | 2 | N.D. | N.D. | O | O | - | Not done |
| Isoform Long of splicing factor, proline- and glutamine-rich (SFPQ) | IPI00010740 | 76 | 28 | 15 | 21 | O | O | - | Not done |
| Scaffold attachment factor B1 (SAFB) | IPI00300631 (+5) | 103 | 5 | 1 | N.D. | O | O | - | Not done |
| X-ray repair cross-complementing protein 5 (XRCC5) | IPI00220834 | 83 | N.D. | 2 | N.D. | O | O | - | Not done |
| Isoform 1 of Mitotic checkpoint protein BUB3 (BUB3) | IPI00013468 (+2) | 37 | 2 | N.D. | 1 | O | O | - | Not done |
| ATP-dependent RNA helicase DDX1 (DDX1) | IPI00293655 (+1) | 82 | 2 | 1 | 1 | O | - | Δ [13] | Not done |
| Isoform 1 of Pogo transposable element with ZNF domain (POGZ) | IPI00410717 (+5) | 155 | 2 | 2 | N.D. | O | - | O [14] | Not done |
| Isoform PLZFA of Zinc finger and BTB domain-containing protein 16 (PLZF) | IPI00220823 (+1) | 62 | N.D. | 2 | N.D. | O | - | Δ [15] | Not done |
| Isoform Short of RNA-binding protein FUS (FUS) | IPI00221354 (+3) | 53 | 41 | 35 | 23 | O | - | Δ [16] | Not done |
| RNA-binding protein EWS isoform 1 (EWS) | IPI00009841 (+4) | 69 | 29 | 24 | 14 | O | - | Δ [17] | Not done |
| Proliferating cell nuclear antigen (PCNA) | IPI00021700 | 29 | N.D. | 1 | 3 | - | O | O [1] | O |
HP1γ, heterochromatin protein 1γ; M. W., molecular weight; N.D., not detected; O, validated by fold ratio, GO, or coimmunoprecipitation experiments (Co-IP Ex). In Article references, references indicated as O report its interaction with HP1γ and functional relation to DNA damage response; references indicated as Δ report only functional relation to DNA damage response.