Table 2.
Cox proportional hazard model and validation from 1,000 bootstrap samples for overall survival in patients with stage I (n=185)
| Variable | Univariate |
Multivariate |
||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | 95% CI (bootstrap) | p-value (bootstrap) | |
| Age (yr)a) | ||||||||
| < 65 | Reference | Reference | ||||||
| ≥ 65 | 2.453 | 1.066-5.646 | 0.035 | 2.480 | 1.076-5.714 | 0.033 | 0.137-1.981 | 0.017 |
| Sexa) | ||||||||
| Female | Reference | Reference | ||||||
| Male | 3.688 | 1.107-12.284 | 0.034 | 4.572 | 1.365-15.316 | 0.014 | 0.525-12.839 | 0.018 |
| Location | ||||||||
| Lower | Reference | - | ||||||
| Upper or middle | 1.204 | 0.536-2.702 | 0.653 | - | - | - | - | - |
| Tumor size (cm)b) | ||||||||
| ≤ 2.7 | Reference | - | ||||||
| > 2.7 | 0.891 | 0.412-1.927 | 0.770 | - | - | - | - | - |
| WHO classification | ||||||||
| W/D or M/D | Reference | - | ||||||
| Othersc) | 0.593 | 0.249-1.411 | 0.237 | - | - | - | - | - |
| Lauren classification | ||||||||
| Intestinal | Reference | - | ||||||
| Diffuse or mixed | 0.985 | 0.395-2.452 | 0.973 | - | - | - | - | - |
| No. of LN dissections | ||||||||
| ≥ 15 | Reference | - | ||||||
| < 15 | 1.752 | 0.760-4.039 | 0.188 | - | - | - | - | - |
| CD44v9a) | ||||||||
| Negative | Reference | Reference | ||||||
| Positive | 2.860 | 1.202-6.805 | 0.017 | 3.375 | 1.413-8.063 | 0.006 | 0.384-2.420 | 0.004 |
HR, hazard ratio; CI, confidence interval; WHO, World Health Organization; W/D, well differentiated; M/D, moderately differentiated; LN, lymph node; CD44v9, CD44 variant 9.
a)
Variables used in multivariate analysis,
b)
Median tumor size was 2.7 cm in stage I,
c)
Poorly differentiated adenocarcinoma, signet-ring cell carcinoma, and mucinous adenocarcinoma were included in this category.