Table 5.
Covariate-adjusted direct, indirect, and total effects for potential mediators (allowing for exposure-mediator interaction) of the 180-day mortality difference between first-generation antipsychotic and second-generation antipsychotic initiators enrolled in Medicare and pharmacy assistance programs in New Jersey and Pennsylvania from 1994 to 2005, assuming particular non-differential and differential mediator misclassification scenarios.
| Naïveb | Non-differential Mediator Misclassificationc | Differential Mediator Misclassificationd | |||||||
|---|---|---|---|---|---|---|---|---|---|
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| PMa (%) |
Direct RR (95% CI) |
Indirect RR (95% CI) |
Total RR (95% CI) |
PMa (%) |
Direct RR (95% CI) |
Indirect RR (95% CI) |
Total RR (95% CI) |
PMa (%) |
|
|
|
|
|
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| Cardiovascular | |||||||||
| Stroke | 5 | 1.13 (1.05-1.2) | 1.010 (1.001-1.02) | 1.14 (1.06-1.22) | 9 | 1.12 (1.04-1.2) | 1.013 (1.002-1.025) | 1.14 (1.06-1.22) | 12 |
| Arrhythmia | 2 | 1.14 (1.06-1.22) | 1.008 (0.992-1.023) | 1.14 (1.07-1.23) | 6 | 1.14 (1.06-1.22) | 1.009 (0.994-1.024) | 1.15 (1.06-1.23) | 7 |
| Myocardial Infarction |
2 | 1.13 (1.06-1.21) | 1.006 (0.999-1.015) | 1.14 (1.07-1.22) | 5 | 1.13 (1.06-1.21) | 1.007 (0.998-1.018) | 1.14 (1.07-1.22) | 6 |
| DVT/PEa | −1 | 1.14 (1.06-1.22) | 0.999 (0.995-1.001) | 1.14 (1.06-1.22) | −1 | 1.13 (1.06-1.22) | 0.998 (0.993-1.001) | 1.13 (1.06-1.21) | −2 |
| Infection | |||||||||
| Pneumonia | 2 | 1.13 (1.06-1.21) | 1.005 (1.001-1.011) | 1.14 (1.07-1.22) | 5 | 1.13 (1.05-1.21) | 1.007 (1.002-1.014) | 1.14 (1.06-1.22) | 6 |
| Bacterial Infectione |
−1 | 1.14 (1.07-1.22) | 1.002 (0.992-1.011) | 1.15 (1.07-1.23) | 1 | 1.15 (1.07-1.22) | 1.002 (0.991-1.015) | 1.15 (1.07-1.23) | 2 |
| Injury | |||||||||
| Hip Fracture | 1 | 1.13 (1.06-1.21) | 1.001 (0.999-1.005) | 1.13 (1.06-1.22) | 1 | 1.13 (1.06-1.21) | 1.002 (1-1.008) | 1.13 (1.06-1.21) | 2 |
Abbreviations: DVT/PE (venous thromboembolism; PM (proportion mediated on risk-difference scale).
Covariate-adjusted proportion mediated without adjustment for medical event misclassification, reproduced from Table 4.
Non-differential misclassification model for all medical events: sensitivity=0.5 and specificity=1.0.
Differential misclassification model for all medical events: sensitivity=0.5 given survival at end of follow-up and 0.25 given death by end of follow-up; specificity=1.0.
Excluding pneumonia.