Table 4.
Survival Analysis
| Univariate | MultivariateŦ | |||
|---|---|---|---|---|
| Variable | Time to Event (mo) | P Value | Hazard Ratio | P Value |
| Treatment Age | 0.4993 | |||
| < 65 y | 6.8 (4.6 - 10.0) | - | ||
| ≥ 65 y | 5.0 (3.6 - 12.5) | - | ||
| Systemic Treatment History | 0.0594 | 0.067 | ||
| < 6 Medications | 4.6 (3.6 - 6.1) | 1.61 (.97 - 2.68) | ||
| ≥ 6 Medications | 8.9 (6.4 - 12.5) | 1.00 | ||
| ECOG Performance Status | 0.3895 | |||
| 0 | 6.7 (5.0 - 10.0) | - | ||
| 1+ | 6.1 (3.5 - 12.3) | - | ||
| Tumor Burden | < 0.0001 | 0.001 | ||
| < 25% | 9.3 (6.7 - 18.7) | .39 (.23 - .66) | ||
| ≥ 25% | 3.9 (2.4 - 5.0) | 1.00 | ||
| Distribution | 0.0665 | 0.558 | ||
| Unilobar | 6.7 (4.0 - 34.7) | .72 (.24 - 2.18) | ||
| Bilobar | 6.4 (4.6 - 9.1) | |||
| No. of Lesions | 0.1062 | 0.705 | ||
| Solitary | 6.7 (4.0 - 34.7) | .81 (.26 - 2.47) | ||
| Multifocal | 6.6 (4.4 - 9.1) | 1.00 | ||
| Bilirubin* | < 0.0001 | 0.005 | ||
| ≤ 1.1 mg/dL | 7.9 (5.8 - 12.3) | 1.00 | ||
| > 1.1 mg/dL | 2.0 (0.5 - 2.6) | 1.38 (1.10 - 1.73) | ||
| Extrahepatic Metastases | 0.095 | 0.164 | ||
| No | 9.3 (5.2 - 23.1) | 1.00 | ||
| Yes | 5.8 (4.0 - 8.9) | 1.59 (0.83 - 3.03) | ||
| Brain Metastases | 0.2906 | |||
| No | 6.4 (4.6 - 12.3) | - | ||
| Yes | 6.8 (2.4 - 9.1) | - | ||
| CA-27.29 Producer* | 0.3061 | |||
| No | 5.0 (3.7 - 7.9) | - | ||
| Yes | 7.9 (4.6 - 12.3) | - | ||
Note.–Values expressed as median (95% confidence interval) where appropriate.
ECOG, Eastern Cooperative Oncology Group.
*
Multivariate analyses adjusted for continuous pre-treatment bilirubin and CA-27.29 values.
Ŧ
Variables included in multivariate Cox proportional hazards model if the proportional hazards assumption was not violated and P was < 0.25 on univariate log-rank testing.