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Epithelial-mesenchymal transition (EMT) occurs when epithelial cells lose their epithelial cell characteristics, including dissolution of cell-cell junctions, i.e. tight junctions (black), adherens junctions (blue) and desmosomes (green), and loss of apical-basolateral polarity, and acquire a mesenchymal phenotype, characterized by actin reorganization and stress fiber formation (red), migration and invasion.
