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. Author manuscript; available in PMC: 2016 Jan 20.
Published in final edited form as: Cell Res. 2009 Feb;19(2):156–172. doi: 10.1038/cr.2009.5

Figure 4.

Figure 4

Signaling crosstalk between the TGF-β-activated Smad pathway and the Wnt- and Notch-activated signaling pathways during EMT. TGF-β signaling interacts with the Wnt pathway at multiple levels, by regulating the activity of β-catenin, or through interactions of Smad complexes with β-catenin and/or TCF/LEF1. TGF-β signaling crosstalks with the Notch pathway, through interactions of Smad complexes with RBPJK/CBF1/Su to regulate EMT-related gene transcription.