Table 2. Anatomical structures showing significant GM abnormalities (a) decreased GM volume at baseline in patients with schizophrenia (n = 20) compared to healthy controls (n = 24); (b) increased GM volume from baseline to follow-up (8 weeks of treatment) in patients with schizophrenia (n = 9).

Anatomical structure	Cluster size (voxel)	t value	Peak Talairach coordinates x, y, z
(a)
Right superior temporal gyrus	50	3.89	56, -6, -11
(b)
Left superior frontal cortex, extending to right superior frontal cortex and left/right supplementary motor area	965	48.20	-2, 22, 40
Right middle frontal cortex	226	34.62	42, 10, 40
Left middle frontal cortex	348	28.78	-22, 22, 46
Left insula	451	27.41	-38, -14, 18
Left superior occipital cortex	147	25.47	-16, -78, 30
Right insula	518	25.11	38, -10, 16
Right cerebellum, extending to left cerebellum	304	23.91	2, -54, -50
Right thalamus	364	23.54	12, -24, 10

(a) Height threshold p<0.001, uncorrected, cluster size = 50;

(b) Height threshold p<0.05, corrected for family-wise error rate, cluster size = 100.