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HMGB1 levels in the myocardium and serum of wt and RAGE-ko mice after AAV9-vector treatment. Wt and RAGE-ko mice were treated with AAV9 vectors (HMGB1 or Luc) and immunized only with CFA. Measurements were done on day 21. (A) Myocardial HMGB1 protein levels were increased in HMGB1-AAV–treated wt and RAGE-ko compared with Luc-AAV mice. (B) HMGB1 levels in serum were increased in HMGB1-AAV–treated wt and RAGE-ko compared with Luc-AAV mice. Error bars indicate mean ± SEM. *P < 0.05.
