Fig. 8.

Reduction in the magnitude of the resting K⁺ currents makes TRPM5 cells sensitive to intracellular acidification. (A) K⁺ (100 mM) elicits significantly larger currents in TRPM5 cells than in PKD2L1 cells and that 10 μM Ba²⁺ reduces the current to a similar magnitude as in PKD2L1 cells. (B) Scatter plot of current magnitudes from cells as shown in A. Tests for significant difference of TRM5 cells with or without Ba²⁺ were against PKD2L1 cells. **P < 0.01 using two-tailed Student’s t test. (C) With the preapplication of 10 μM Ba²⁺, robust action potentials were elicited by 100 mM propionic acid at pH 7.4. (D) The average data of cells as in C. **P < 0.01 using paired one-tailed Student’s t test.